000133620 001__ 133620
000133620 005__ 20190316234457.0
000133620 0247_ $$2doi$$a10.1242/dev.028621
000133620 02470 $$2ISI$$a000262692500013
000133620 037__ $$aARTICLE
000133620 245__ $$aRostral and caudal pharyngeal arches share a common neural crest ground pattern
000133620 269__ $$a2009
000133620 260__ $$c2009
000133620 336__ $$aJournal Articles
000133620 520__ $$aIn vertebrates, face and throat structures, such as jaw, hyoid and thyroid cartilages develop from a rostrocaudal metameric series of pharyngeal arches, colonized by cranial neural crest cells (NCCs). Colinear Hox gene expression patterns underlie arch specific morphologies, with the exception of the first (mandibular) arch, which is devoid of any Hox gene activity. We have previously shown that the first and second (hyoid) arches share a common, Hox-free, patterning program. However, whether or not more posterior pharyngeal arch neural crest derivatives are also patterned on the top of the same ground-state remained an unanswered question. Here, we show that the simultaneous inactivation of all Hoxa cluster genes in NCCs leads to multiple jaw and first arch-like structures, partially replacing second, third and fourth arch derivatives, suggesting that rostral and caudal arches share the same mandibular arch-like ground patterning program. The additional inactivation of the Hoxd cluster did not significantly enhance such a homeotic phenotype, thus indicating a preponderant role of Hoxa genes in patterning skeletogenic NCCs. Moreover, we found that Hoxa2 and Hoxa3 act synergistically to pattern third and fourth arch derivatives. These results provide insights into how facial and throat structures are assembled during development, and have implications for the evolution of the pharyngeal region of the vertebrate head.
000133620 6531_ $$aHox genes
000133620 6531_ $$aHead morphogenesis
000133620 6531_ $$aHyoid bone
000133620 6531_ $$aJaw development
000133620 6531_ $$aMouse
000133620 6531_ $$aNeural crest cells
000133620 700__ $$aMinoux, M.
000133620 700__ $$aAntonarakis, G. S.
000133620 700__ $$aKmita, M.
000133620 700__ $$0240276$$g141236$$aDuboule, D.
000133620 700__ $$aRijli, F. M.
000133620 773__ $$j136$$tDevelopment$$k4$$q637-645
000133620 8564_ $$uhttps://infoscience.epfl.ch/record/133620/files/2009_Rostral%20and%20caudal%20pharyngeal%20arches.pdf$$zn/a$$s4293577
000133620 909C0 $$xU11705$$0252099$$pUPDUB
000133620 909CO $$ooai:infoscience.tind.io:133620$$qGLOBAL_SET$$pSV$$particle
000133620 937__ $$aUPDUB-ARTICLE-2009-001
000133620 973__ $$rREVIEWED$$sPUBLISHED$$aEPFL
000133620 980__ $$aARTICLE