Bacterial pore-forming toxins: the (w)hole story?

Pore-forming toxins (PFTs) are the most common class of bacterial protein toxins and constitute important bacterial virulence factors. The mode of action of PFT is starting to be better understood. In contrast, little is known about the cellular response to this threat. Recent studies reveal that cells do not just swell and lyse, but are able to sense and react to pore formation, mount a defense, even repair the damaged membrane and thus survive. These responses involve a variety of signal-transduction pathways and sophisticated cellular mechanisms such as the pathway regulating lipid metabolism. In this review we discuss the different classes of bacterial PFTs and their modes of action, and provide examples of how the different bacteria use PFTs. Finally, we address the more recent field dealing with the eukaryotic cell response to PFT-induced damage

Published in:
Cell Mol Life Sci, 65, 3, 493-507
Author address: Ecole Polytechnique Fédérale de Lausanne, Global Health Institute, Station 15, 1015 Lausanne, Switzerland
Other identifiers:

 Record created 2009-02-02, last modified 2018-09-13

Rate this document:

Rate this document:
(Not yet reviewed)