Aerolysin from Aeromonas hydrophila and related toxins

Aeromonads are ubiquitous gram-negative bacteria found in aqueous environments. Some members of the genus are pathogenic for fish, reptiles and cows. In humans, Aeromonas infection is mainly associated with grastrointestinal diseases, but in immuno-compromised individuals infection can lead to septicemia and meningitis (Austin et al. 1996). Aeromonas secretes a variety of virulence factors amongst which aerolysin is the best characterized. Using marker exchange mutagenesis, aerolysin was demonstrated to be required not only for the establishment but also for the subsequent maintenance of systemic infections associated with the bacterium (Chakraborty et al. 1987). Furthermore, specific neutralizing antibodies to aerolysin have been detected in animals surviving Aeromonas infection.


Published in:
Current Topics in Microbiology and Immunology, 257, 35-52
Year:
2001
ISSN:
0070-217X
Keywords:
Note:
Department of Biochemistry, Faculty of Sciences, University of Geneva, 30 Quai Ernest-Ansermet, 1211 Geneva, Switzerland.
Laboratories:




 Record created 2009-01-30, last modified 2018-09-13


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