000131181 001__ 131181
000131181 005__ 20190213070419.0
000131181 037__ $$aPROC
000131181 245__ $$aPredicting locomotor activity via neural ensemble recordings in the primary motor cortex in rats.
000131181 269__ $$a2008
000131181 260__ $$bSFN$$c2008$$aSan Diego, CA.
000131181 336__ $$aConference Proceedings
000131181 520__ $$aThe possibility to use information from cortical neurons to drive neuroprosthetic devices is an area that has recently garnered a lot of attention within neuroscience. Most of this research has been directed towards restoring upper limb motility. In this study, we have started to assess the possibility of using cortical neurons to drive a lower limb neuroprosthetic device. Rats were chronically implanted with multielectrode arrays (consisting of between 32-96 electrodes wires) in the primary motor cortex. Neuronal activity (both spikes and local field potentials) were recorded while the animals walked on a treadmill. Joint and limb positions were captured using UV marks placed on the animal and captured in 3D at 100Hz using four high-speed cameras and motion capture software. An artificial model of the rats movement was then reconstructed to use as a comparison for the neuronal model. Spikes were sorted offline and different units were shown to be significantly responsive to locomotor activity. These spikes were binned and used as regressors in a linear filter, with joint positions modeled as a weighted linear combination of neuronal activity using multidimensional linear regression. Preliminary performances of the linear models suggest that the cortical activity can predict the actual motor activity well (up to R2 = 0.64). This indicates that there is some correlation between higher cortical activity in MI and locomotor activity. It also indicates that cortical activity may be useful for controlling a neuroprosthetic or robotic device, at even a low-level of control.
000131181 6531_ $$aelctrophisiology
000131181 6531_ $$aneuroprosthetic
000131181 6531_ $$aBrain machine interfaces
000131181 7112_ $$d2007$$cSan Diego, CA$$aSociety for Neuroscience
000131181 720_1 $$aTate, A.J.$$eed.
000131181 720_1 $$aShokur, S.$$eed.$$g128971$$0242144
000131181 720_1 $$aBleuler, H.$$eed.$$g104561$$0240027
000131181 720_1 $$aNicolelis, M.A.L.$$eed.
000131181 909C0 $$0252016$$pLSRO
000131181 909CO $$ooai:infoscience.tind.io:131181$$pSTI$$pproc
000131181 937__ $$aLSRO-PROC-2009-001
000131181 973__ $$sPUBLISHED$$aEPFL
000131181 980__ $$aPROC