000130897 001__ 130897
000130897 005__ 20180317092905.0
000130897 0247_ $$2doi$$a10.1021/bk-2009-1003.ch002
000130897 020__ $$a978-0-8412-6953-8
000130897 02470 $$2ISI$$a000289050300002
000130897 037__ $$aBOOK_CHAP
000130897 245__ $$aSite Selective Functionalization of Fluorinated Nitrogen Heterocycles
000130897 260__ $$aWashington, DC$$bAmerican Chemical Society$$c2009
000130897 269__ $$a2009
000130897 336__ $$aBook Chapters
000130897 490__ $$aACS Symposium Series$$v1003
000130897 520__ $$aFunctional groups are prerequisites for the assembly of building blocks to more elaborate structures for research work in the life sciences field.  Functionalization can be most conveniently and efficaciously accomplished by generating an organometallic deriv. of the arom. or heterocyclic starting material and subsequently treating it with the electrophile of choice.  The presence of heterosubstituents facilitates immensely the introduction of the metal (by permutational halogen/metal or hydrogen/metal interconversion) and at the same time enables a perfect control of the desired regioselectivity as will be illustrated by typical examples selected from the indole, pyrazoles, pyridine and quinoline fields.
000130897 6531_ $$aRegioselective Ortho-Lithiation
000130897 6531_ $$aVinyl Grignard-Reagents
000130897 6531_ $$aMetalation
000130897 6531_ $$aGeneration
000130897 6531_ $$aPyridines
000130897 6531_ $$aFluoroquinolines
000130897 6531_ $$aHalopyridines
000130897 6531_ $$aElaboration
000130897 6531_ $$aMethodology
000130897 6531_ $$aNitroarenes
000130897 700__ $$0240930$$aSchlosser, Manfred$$g123541
000130897 700__ $$0240739$$aBorel, Alain$$g148230
000130897 700__ $$0241578$$aPatiny, Luc$$g148588
000130897 720_1 $$aGakh, Andrei A.$$eed.
000130897 720_1 $$aKirk, Kenneth L.$$eed.
000130897 773__ $$q23-37$$tFluorinated Heterocycles
000130897 909CO $$ooai:infoscience.tind.io:130897$$pSB$$pchapter
000130897 909C0 $$0252140$$pISIC-GE$$xU10096
000130897 909C0 $$0252181$$pLSCO
000130897 917Z8 $$x148230
000130897 937__ $$aLSCO-CHAPTER-2009-001
000130897 973__ $$aEPFL$$sPUBLISHED
000130897 980__ $$aCHAPTER