000130658 001__ 130658
000130658 005__ 20190316234443.0
000130658 02470 $$2ISI$$a000264876700083
000130658 037__ $$aCONF
000130658 245__ $$aCircuits Design and Nano-Structured Electrodes for Drugs Monitoring in Personalized Therapy
000130658 260__ $$bIEEE$$c2008
000130658 269__ $$a2008
000130658 336__ $$aConference Papers
000130658 520__ $$aDrug development and personalized therapy require accurate and frequent monitoring of the metabolic response by living tissues to treatments. In case of high risk side effects, e.g. therapies with interfering anti-cancer molecule cocktails, direct monitoring of the patient’s drugs metabolism is essential as the metabolic pathways efficacy is highly variable on a patient-by-patient basis. Currently, there are no fully mature point-of-care bio-sensing systems for drugs metabolism monitoring directly in blood. The aim of the paper is to investigate solutions to develop point-of-care systems for drugs monitoring in personalized therapy. P450 enzymes are the considered probe molecules as they are key proteins directly involved in drugs metabolism of humans. Sensitivity improvement is ensured by means of enzyme integration onto electrodes structured with carbon nanotubes. Component Off-The-Shelf (COTS) based circuits design is investigated toward bio-chip development. Results show that the proposed circuitry is suitable for the aim and confirm that nanotubes are detection enhancers.
000130658 700__ $$0242413$$g182237$$aCarrara, Sandro
000130658 700__ $$0242421$$g176841$$aCavallini, Andrea
000130658 700__ $$0240269$$g167918$$aDe Micheli, Giovanni
000130658 700__ $$0242419$$g183208$$aOlivo, Jacopo
000130658 700__ $$aBenini, Luca$$g171049$$0243773
000130658 700__ $$aShumyantseva, Victoria V.
000130658 700__ $$aArhakov, Alexander I.
000130658 7112_ $$d November 20-22, 2008$$cBaltimore, Maryland, USA$$aIEEE Biomedical Circuits and Systems Conference (BioCAS)
000130658 773__ $$tProceedings of the IEEE Biomedical Circuits and Systems Conference (BioCAS)
000130658 8564_ $$uhttps://infoscience.epfl.ch/record/130658/files/BioCAS-2008-Circuits-%26-Nano.pdf$$zn/a$$s311421$$yn/a
000130658 909C0 $$xU11140$$0252283$$pLSI1
000130658 909CO $$pIC$$qGLOBAL_SET$$ooai:infoscience.tind.io:130658$$pconf$$pSTI
000130658 917Z8 $$x112915
000130658 937__ $$aEPFL-CONF-130658
000130658 973__ $$rREVIEWED$$sPUBLISHED$$aEPFL
000130658 980__ $$aCONF