000129682 001__ 129682
000129682 005__ 20190316234429.0
000129682 02470 $$2ISI$$a000265462400007
000129682 037__ $$aARTICLE
000129682 245__ $$aEstimating the Confidence Level of White Matter Connections Obtained with MRI Tractography
000129682 269__ $$a2008
000129682 260__ $$c2008
000129682 336__ $$aJournal Articles
000129682 520__ $$aBackground Since the emergence of diffusion tensor imaging, a lot of work has been done to better understand the properties of diffusion MRI tractography. However, the validation of the reconstructed fiber connections remains problematic in many respects. For example, it is difficult to assess whether a connection is the result of the diffusion coherence contrast itself or the simple result of other uncontrolled parameters like for example: noise, brain geometry and algorithmic characteristics. Methodology / principal findings In this work, we propose a method to estimate the respective contributions of diffusion coherence versus other effects to a tractography result by comparing data sets with and without diffusion coherence contrast. We use this methodology to assign a confidence level to every gray matter to gray matter connection and add this new information directly in the connectivity matrix. Conclusions / significance Our results demonstrate that whereas we can have a strong confidence in mid- and long-range connections obtained by a tractography experiment, it is difficult to distinguish between short connections traced due to diffusion coherence contrast from those produced by chance due to the other uncontrolled factors of the tractography methodology.
000129682 6531_ $$aDiffusion MRI
000129682 6531_ $$aTractography
000129682 6531_ $$aLTS5
000129682 700__ $$aGigandet, Xavier
000129682 700__ $$0240859$$aHagmann, Patric$$g140571
000129682 700__ $$aKurant, Maciej
000129682 700__ $$0243801$$aCammoun, Leila$$g201473
000129682 700__ $$0243802$$aMeuli, Reto$$g141496
000129682 700__ $$0240323$$aThiran, Jean-Philippe$$g115534
000129682 773__ $$tPLoSONE
000129682 8564_ $$zURL
000129682 8564_ $$s591438$$uhttps://infoscience.epfl.ch/record/129682/files/journal.pone.0004006.pdf$$zn/a
000129682 909C0 $$0252394$$pLTS5$$xU10954
000129682 909CO $$ooai:infoscience.tind.io:129682$$pSTI$$particle$$qGLOBAL_SET
000129682 937__ $$aEPFL-ARTICLE-129682
000129682 973__ $$aEPFL$$rREVIEWED$$sPUBLISHED
000129682 980__ $$aARTICLE