Microfluidics-generated immobilized biomolecule gradients on hydrogels

Extra-cellular matrix (ECM) tethered morphogen gradients play an important role in tissue development and regeneration. There is currently only a limited set of model systems which can mimic these gradients in an artificial ECM-like environment. We have developed such a system that is able to stably immobilize a microfluidics-generated protein gradient on a poly(ethylene) glycol (PEG) hydrogel. After patterning, the hydrogel can be released from the chip and be directly used for cell culture.


Editor(s):
Locascio, Laurie E.
Gaitan, Michael
Paegel, Brian M.
Ross, David J.
Vreeland, Wyatt N.
Published in:
Proceedings of MicroTAS 2008, 2, 1549-1552
Presented at:
MicroTAS: The Twelfth International Conference on Miniaturized Systems for Chemistry and Life Sciences, San Diego, CA, USA, October 12 -16, 2008
Year:
2008
Publisher:
The Chemical and Biological Microsystems Society
Keywords:
Laboratories:


Note: The status of this file is: EPFL only


 Record created 2008-11-21, last modified 2018-01-28

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