Beta-amyloid deposition and Alzheimer's type changes induced by Borrelia spirochetes

The pathological hallmarks of Alzheimer's disease (AD) consist of P-amyloid plaques and neurofibrillary tangles in affected brain areas. The processes, which drive this host reaction are unknown. To determine whether an analogous host reaction to that occurring in AD could be induced by infectious agents, we exposed mammalian glial and neuronal cells in vitro to Borrelia burgdorferi spirochetes and to the inflammatory bacterial lipopolysaccharide (LPS). Morphological changes analogous to the amyloid deposits of AD brain were observed following 2-8 weeks of exposure to the spirochetes. Increased levels of beta-amyloid presursor protein (A beta PP) and hyperphosphorylated tau were also detected by Western blots of extracts of cultured cells that had been treated with spirochetes or LPS. These observations indicate that, by exposure to bacteria or to their toxic products, host responses similar in nature to those observed in AD may be induced. (C) 2005 Elsevier Inc. All rights reserved.


Published in:
Neurobiology of Aging, 27, 2, 228-236
Year:
2006
Publisher:
Elsevier
ISSN:
0197-4580
Keywords:
Note:
Miklossy, J Univ British Columbia, Kinsmen Lab Neurol Res, 2255 Wesbrook Mall, Vancouver, BC V6T 1Z3, Canada Univ British Columbia, Kinsmen Lab Neurol Res, Vancouver, BC V6T 1Z3, Canada CHU Vaudois, Univ Med Sch, Univ Inst Pathol, Div Neuropathol, CH-1011 Lausanne, Switzerland Swiss Fed Inst Technol, Dept Phys, CH-1015 Lausanne, Switzerland Brookhaven Natl Lab, Natl Synchrotron Light Source, Upton, NY 11973 USA Univ Western Australia, Hollywood Private Hosp, Sch Psychiat & Clin Neurosci, Sir James McCusker Alzheimers Dis Res Unit, Perth, WA 6009, Australia Temple Univ, Coll Sci & Technol, Ctr Neurovirol & Canc Biol, Philadelphia, PA 19122 USA SUNY Stony Brook, Dept Phys & Astron, Stony Brook, NY 11794 USA, 004WD, Times Cited:7, Cited References Count:35
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