000129013 001__ 129013
000129013 005__ 20190316234419.0
000129013 0247_ $$2doi$$a10.1016/j.irbm.2008.10.003
000129013 02470 $$2ISI$$a000265044200003
000129013 02470 $$2ISI$$a000269257300072
000129013 02470 $$2ISI$$a000266012700003
000129013 037__ $$aARTICLE
000129013 245__ $$aOsteoclastogenesis can be mechanically-induced in the peri-implant bone
000129013 269__ $$a2009
000129013 260__ $$c2009
000129013 336__ $$aJournal Articles
000129013 520__ $$aTotal joint replacements are highly successful in relieving pain and restoring movement of damaged joints. However, the lifespan of the implants is limited. The implant’s long-term stability depends largely on the preservation of periprosthetic bone. Debris-wear particulates were first identified as the factor inducing periprosthetic bone loss. However, it was later shown that the resorption process starts before the particulates reach the periprosthetic bone. Thus a mechanical factor, interface micromotions, has been suspected to be the initiator of the early bone loss. In this work, we then investigated the response of bone cells to micromotions. Using an ex vivo setup, we applied micromotions on fresh human bone cores and showed that micromotions could indirectly activate osteoclasts after only 1 hour of stimulation. Thus micromotion-related osteoclastic activity could be the initiator of periprosthetic bone loss.
000129013 6531_ $$aMechanical stimulation
000129013 6531_ $$aex vivo
000129013 6531_ $$ahuman bone
000129013 6531_ $$aRANKL
000129013 6531_ $$aOPG
000129013 700__ $$aStadelmann, Vincent
000129013 700__ $$0240310$$aTerrier, Alexandre$$g106533
000129013 700__ $$0240508$$aPioletti, Dominique P.$$g103117
000129013 773__ $$j30$$k1$$q10-13$$tBiomedical Engineering and Research
000129013 8564_ $$zURL
000129013 8564_ $$s276679$$uhttps://infoscience.epfl.ch/record/129013/files/IRBM-Vincent%282009%29.pdf$$zn/a
000129013 909C0 $$0252108$$pLBO$$xU10299
000129013 909CO $$ooai:infoscience.tind.io:129013$$pSTI$$particle$$qGLOBAL_SET
000129013 937__ $$aLBO-ARTICLE-2008-020
000129013 973__ $$aEPFL$$rREVIEWED$$sPUBLISHED
000129013 980__ $$aARTICLE