Functional characterization of Pneumocystis carinii brl1 by transspecies complementation analysis
2007
Abstract
Pneumocystis jirovecii is a fungus which causes severe opportunistic infections in immunocompromised humans. The brl1 gene of P. carinii infecting rats was identified and characterized by using bioinformatics in conjunction with functional complementation in Saccharomyces cerevisiae and Schizosaccharomyces pombe. The ectopic expression of this gene rescues null alleles of essential nuclear membrane proteins of the Brr6/Brl1 family in both yeasts.
Details
Title
Functional characterization of Pneumocystis carinii brl1 by transspecies complementation analysis
Author(s)
Lo Presti, L. ; Cockell, M. ; Cerutti, L. ; Simanis, V. ; Hauser, P. M.
Published in
Eukaryot Cell
Volume
6
Issue
12
Pages
2448-52
Date
2007
Keywords
Alleles; Amino Acid Sequence; Animals; Computational Biology; *Gene Expression Regulation; Fungal; *Genetic Complementation Test; Membrane Proteins/genetics/physiology; Molecular Sequence Data; Nuclear Proteins/*genetics/*physiology; Pneumocystis carinii/*metabolism; Rats; Saccharomyces cerevisiae/metabolism; Saccharomyces cerevisiae Proteins/*genetics/*physiology; Schizosaccharomyces/metabolism; Sequence Homology; Amino Acid; Species Specificity
Other identifier(s)
DAR: 11944
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Laboratories
UPSIM
Record Appears in
Scientific production and competences > SV - School of Life Sciences > ISREC - Swiss Institute for Experimental Cancer Research > UPSIM - Prof. Simanis Group
Peer-reviewed publications
Work produced at EPFL
Journal Articles
Published
Peer-reviewed publications
Work produced at EPFL
Journal Articles
Published
Record creation date
2008-10-21