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research article
Contribution of microwaves in organic synthesis: statement of a methodology for the microwave-induced preparation of benzofuran-2(3H)-one and its comparison with classical heating
The intramolecular cyclisation of 2-hydroxyphenylacetic acid 1 into coumaran-2-one 2 was studied under both microwave irradiation and classical heating for comparison purposes. The use of a monomode oven allowed an accurate consideration of the temperature distribution in the microwave reaction vessel, which revealed a very strong and unexpected thermal heterogeneity. The reaction was facilitated by the presence of a trace of toluene-p-sulfonic acid, the catalytic role of which is demonstrated.
Type
research article
Authors
Publication date
1999
Issue
10
Start page
2111
End page
2115
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
October 21, 2008
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