Contribution of microwaves in organic synthesis: statement of a methodology for the microwave-induced preparation of benzofuran-2(3H)-one and its comparison with classical heating

The intramolecular cyclisation of 2-hydroxyphenylacetic acid 1 into coumaran-2-one 2 was studied under both microwave irradiation and classical heating for comparison purposes. The use of a monomode oven allowed an accurate consideration of the temperature distribution in the microwave reaction vessel, which revealed a very strong and unexpected thermal heterogeneity. The reaction was facilitated by the presence of a trace of toluene-p-sulfonic acid, the catalytic role of which is demonstrated.

Published in:
Journal of the Chemical Society, Perkin Transactions 2, 10, 2111-2115

 Record created 2008-10-21, last modified 2018-03-17

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