000126409 001__ 126409
000126409 005__ 20190316234331.0
000126409 0247_ $$2doi$$a10.1021/ic800842f
000126409 02470 $$2ISI$$a000258709500046
000126409 037__ $$aARTICLE
000126409 245__ $$aRemarkable Tuning of the Photophysical Properties of Bifunctional Lanthanide tris(Dipicolinates) and its Consequence on the Design of Bioprobes
000126409 269__ $$a2008
000126409 260__ $$c2008
000126409 336__ $$aJournal Articles
000126409 520__ $$aDerivatives of dipicolinic acid with a polyoxyethylene pendant arm at the pyridine 4-position have been functionalized for potential grafting with biological material. Four ligands with different terminal functions (alcohol, methoxy, phtalimide and amine) have been synthesized, which react with trivalent lanthanide ions $Ln^{III}$ to yield triple helical $[Ln(L)_3]^{3-}$ complexes, as shown by NMR and UV-vis titrations. The tris chelates display large thermodynamic stability with $log \beta_{13} \approx 19-20$ for all $Eu^{III}$ complexes for instance. Photophysical measurements reveal adequate sensitization of the metal-centered luminescence in the europium ($\eta_{sens} = 33-72\%$) and terbium complexes, which is modulated by the nature of the terminal function. The lifetimes of the metal-centered excited states are long, up to 1.4 ms for $[Eu(L)_3]^{3-}$ and 1.6 ms for $[Tb(L)_3]^{3-}$ at room temperature, in line with hydration numbers essentially equal to zero. Quantum yields are as high as 29% for the $[Eu(L^{NH2})_3]^{3-}$ and 18% for the $[Tb(L^{OH})_3]^{3-}$ tris chelates in water at physiological pH. These series of complexes demonstrate the extent of fine-tuning achievable for lanthanide luminescent probes and are simple models for investigating the effect of binding to biological molecules on the metal-centered luminescent properties.
000126409 700__ $$aGassner, Anne-Laure
000126409 700__ $$aDuhot, Céline
000126409 700__ $$0241990$$g122803$$aBünzli, Jean-Claude G.
000126409 700__ $$0240735$$g149479$$aChauvin, Anne-Sophie
000126409 773__ $$j47$$tInorganic Chemistry$$q7802-7812
000126409 8564_ $$uhttps://infoscience.epfl.ch/record/126409/files/IC-08-Dipic-ALG.pdf$$zn/a$$s644613
000126409 909C0 $$xU10099$$0252081$$pLCSL
000126409 909CO $$ooai:infoscience.tind.io:126409$$qGLOBAL_SET$$pSB$$particle
000126409 937__ $$aLCSL-ARTICLE-2008-025
000126409 973__ $$rREVIEWED$$sPUBLISHED$$aEPFL
000126409 980__ $$aARTICLE