Abstract
Asymmetric cell division is fundamental for generating diversity in multicellular organisms. The mechanisms that govern asymmetric cell division are increasingly well understood, owing notably to studies that were conducted in Drosophila melanogaster and Caenorhabditis elegans. Lessons learned from these two model organisms also apply to cells that divide asymmetrically in other metazoans, such as self-renewing stem cells in mammals
Details
Title
Mechanisms of asymmetric cell division: flies and worms pave the way
Author(s)
Gönczy, Pierre
Published in
Nature reviews. Molecular cell biology
Volume
9
Issue
5
Pages
355-366
Date
2008
Keywords
Animals; Caenorhabditis elegans/cytology; Cell Cycle Proteins/metabolism; Cell Division/physiology; Cell Polarity; Centrosome/metabolism; Drosophila Proteins/genetics/metabolism; Drosophila melanogaster/cytology; Embryo; Nonmammalian/cytology/physiology; GTP-Binding Protein alpha Subunits/metabolism; Helminth Proteins/genetics/metabolism; Juvenile Hormones/genetics/metabolism; Mitotic Spindle Apparatus/metabolism/ultrastructure; Protein Folding; Receptors; Notch/genetics/metabolism; Signal Transduction/physiology; Ubiquitin-Protein Ligases/genetics/metabolism
Note
Author address: Swiss Institute for Experimental Cancer Research (ISREC), Swiss Federal Institute of Technology (EPFL), School of Life Sciences, Lausanne, Switzerland
Other identifier(s)
View record in Web of Science
DAR: 12481
DAR: 12481
Laboratories
UPGON
Record Appears in
Scientific production and competences > SV - School of Life Sciences > ISREC - Swiss Institute for Experimental Cancer Research > UPGON - Prof. Gönczy Group
Peer-reviewed publications
Work produced at EPFL
Published
Reviews
Peer-reviewed publications
Work produced at EPFL
Published
Reviews
Record creation date
2008-08-31