Importance of the p-Ligand: Remarkable Effect of the Cyclopentadienyl Ring on the Cytotoxicity of Ruthenium PTA Compounds
Dutta, Barnali; Scolaro, Claudine; Scopelliti, Rosario; Dyson, Paul J.; Severin, Kay.
2008

Abstract

The water-sol. complexes [(Cp'OR)RuCl(PTA)2] (Cp'OR = h5-1-alkoxy-2,4-di-tert-butyl-3-neopentylcyclopentadienyl; R = Me, Et; PTA = 1,3,5-triaza-7-phosphaadamantane) are considerably more cytotoxic (.apprx.2 orders of magnitude) than the cyclopentadienyl analog [CpRuCl(PTA)2] (i.e., IC50 = 4-10 vs. >1000 mM, depending on the cell line). The structure of [(Cp'OMe)RuCl(PTA)2] is reported, together with that of the precursor [(Cp'OEt)Ru(m-Cl)]2.

Details

Title Importance of the p-Ligand: Remarkable Effect of the Cyclopentadienyl Ring on the Cytotoxicity of Ruthenium PTA Compounds
Author(s) Dutta, Barnali ; Scolaro, Claudine ; Scopelliti, Rosario ; Dyson, Paul J. ; Severin, Kay.
Published in Organometallics
Volume 27
Issue 7
Pages 1355-1357
Date 2008
DOI https://doi.org/10.1021/om800025a
Other identifier(s) View record in Web of Science
DAR: 12665
Laboratories LCOM
LCS
Record Appears in Scientific production and competences > SB - School of Basic Sciences > ISIC - Institute of Chemical Sciences and Engineering > LCOM - Laboratory of Organometallic and Medicinal Chemistry
Scientific production and competences > SB - School of Basic Sciences > ISIC - Institute of Chemical Sciences and Engineering > LCS - Laboratory of Supramolecular Chemistry
Peer-reviewed publications
Work produced at EPFL
Journal Articles
Published
Record creation date 2008-07-29