000125769 001__ 125769
000125769 005__ 20180913054649.0
000125769 037__ $$aCONF
000125769 245__ $$aTinkering with constraints in the evolution of the vertebrate limb anterior-posterior polarity
000125769 269__ $$a2007
000125769 260__ $$c2007
000125769 336__ $$aConference Papers
000125769 520__ $$aGenes belonging to both HoxA and HoxD clusters are required for proper vertebrate limb development. Mice lacking all, or parts of, Hoxa and Hoxd functions in forelimbs, as well as mice with a gain of function of these genes in the early limb bud, have helped us to understand functional and regulatory issues associated with these genes, such that, for example, the tight mechanistic interdependency that exists between the production of the limb and its anterior to posterior (AP) polarity. Our studies suggest that the evolutionary recruitment of Hox gene function into growing appendages was crucial to implement hedgehog signalling, subsequently leading to the distal extension of tetrapod appendages, with an already built-in AP polarity. We propose that this process results from the evolutionary co-option, in the developing limbs, of a particular regulatory mechanism (collinearity), which is necessary to pattern the developing trunk. This major regulatory constraint imposed a polarity to our limbs as the most parsimonious solution to grow appendages.
000125769 700__ $$aDuboule, D
000125769 700__ $$aTarchini, B
000125769 700__ $$aZakany, J
000125769 700__ $$aKmita, M
000125769 7112_ $$aNovartis Foundation Symposium
000125769 773__ $$q130-7; discussion 138-41, 158-63
000125769 909C0 $$xU11705$$0252099$$pUPDUB
000125769 909CO $$pconf$$pSV$$ooai:infoscience.tind.io:125769
000125769 937__ $$aUPDUB-CONF-2008-012
000125769 973__ $$rREVIEWED$$sPUBLISHED$$aEPFL
000125769 980__ $$aCONF