000124962 001__ 124962
000124962 005__ 20181203021243.0
000124962 0247_ $$2doi$$a10.1103/PhysRevE.78.011914
000124962 022__ $$a1095-3787
000124962 02470 $$2DAR$$a13161
000124962 02470 $$2ISI$$a000258178600083
000124962 037__ $$aARTICLE
000124962 245__ $$aSpike-triggered averages for passive and resonant neurons receiving filtered excitatory and inhibitory synaptic drive
000124962 269__ $$a2008
000124962 260__ $$c2008
000124962 336__ $$aJournal Articles
000124962 520__ $$aA path-integral approach is developed for the analysis of spike-triggered-average quantities in neurons with voltage-gated subthreshold currents. Using a linearization procedure to reduce the models to the generalized integrate-and-fire form, analytical expressions are obtained in an experimentally relevant limit of fluctuation-driven firing. The influences of voltage-gated channels as well as excitatory and inhibitory synaptic filtering are shown to affect significantly the neuronal dynamics prior to the spike. Analytical forms are given for all relevant physiological quantities, such as the mean voltage triggered to the spike, mean current flowing through voltage-gated channels and the mean excitatory and inhibitory conductance wave forms prior to a spike. The mathematical results are shown to be in good agreement with numerical simulations of the underlying non-linear conductance-based models. The method promises to provide a useful analytical tool for the prediction and interpretation of the temporal structure of spike-triggered averages measured experimentally.
000124962 700__ $$0240327$$aBadel, L.$$g119183
000124962 700__ $$0240007$$aGerstner, W.$$g111732
000124962 700__ $$aRichardson, J. E.
000124962 773__ $$j78$$k1$$q011914 1-12$$tPHYSICAL REVIEW E
000124962 8564_ $$zURL
000124962 8564_ $$s949530$$uhttps://infoscience.epfl.ch/record/124962/files/Badel08.pdf$$zn/a
000124962 909C0 $$0252006$$pLCN
000124962 909CO $$ooai:infoscience.tind.io:124962$$particle$$pSV$$pIC
000124962 917Z8 $$x180892
000124962 937__ $$aLCN-ARTICLE-2008-011
000124962 973__ $$aEPFL$$rREVIEWED$$sPUBLISHED
000124962 980__ $$aARTICLE