The Southern African Development Community (SADC) has evolved in 1992 from the former Southern African Development Coordination Conference (SADCC) existing since 1980. The SADC aims at regional integration, sustainable growth and alleviation of poverty in the member countries. Fourteen countries make up the Southern African Development Community (SADC): Angola, Botswana, Democratic Republic of Congo, Lesotho, Madagascar, Malawi, Mauritius, Mozambique, Namibia, Seychelles, South Africa, Swaziland, Tanzania, Zambia and Zimbabwe. Biofuels production represents an opportunity for the region to increase energy supply security and to give a boost to rural economies by opening markets for agricultural surpluses, creating jobs and encouraging mechanization of agricultural practices. However, climatic, agronomic, ecological and policy factors can hamper the industry development in the region. In that sense, a clear definition of objectives and a careful implementation that takes into account sustainability as well as socio-economic aspects are much needed from policy makers.