Neural Differentiation of Expected Reward and Risk in Human Subcortical Structures

In decision-making under uncertainty, economic studies emphasize the importance of risk in addition to expected reward. Studies in neuroscience focus on expected reward and learning rather than risk. We combined functional imaging with a simple gambling task to vary expected reward and risk simultaneously and in an uncorrelated manner. Drawing on financial decision theory, we modeled expected reward as mathematical expectation of reward, and risk as reward variance. Activations in dopaminoceptive structures correlated with both mathematical parameters. These activations differentiated spatially and temporally. Temporally, the activation related to expected reward was immediate, while the activation related to risk was delayed. Analyses confirmed that our paradigm minimized confounds from learning, motivation, and salience. These results suggest that the primary task of the dopaminergic system is to convey signals of upcoming stochastic rewards, such as expected reward and risk, beyond its role in learning, motivation, and salience. © 2006 Elsevier Inc. All rights reserved.


Published in:
Neuron, 51, 3, 381-390
Year:
2006
Keywords:
Note:
Computation and Neural Systems Program, Social Cognitive Neuroscience Laboratory, California Institute of Technology, 1200 East California Blvd, 228-77, Pasadena, CA 91125, United States Division of Humanities and Social Sciences, California Institute of Technology, 1200 East California Blvd, 228-77, Pasadena, CA 91125, United States
TY - JOUR
Cited By (since 1996): 19
Export Date: 10 March 2008
Source: Scopus
Other identifiers:
Scopus: 2-s2.0-33746711623
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 Record created 2008-03-12, last modified 2018-03-17


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