000117958 001__ 117958
000117958 005__ 20180707190757.0
000117958 0247_ $$2doi$$a10.1021/nl0720408
000117958 02470 $$2ISI$$a000253166200008
000117958 037__ $$aARTICLE
000117958 245__ $$aGadonanotubes as Ultrasensitive pH-Smart Probes for  Magnetic Resonance Imaging
000117958 269__ $$a2008
000117958 260__ $$c2008
000117958 336__ $$aJournal Articles
000117958 520__ $$aWith their nanoscalar, superparamagnetic Gd3+-ion clusters  (1 ´ 5 nm) confined within ultrashort (20-80 nm) single- walled carbon nanotube capsules, gadonanotubes are high- performance T1-weighted contrast agents for magnetic  resonance imaging (MRI). At 1.5 T, 37 °C, and pH 6.5, the  r1 relaxivity (ca. 180 mM-1 s-1 per Gd3+ ion) of  gadonanotubes is 40 times greater than any current Gd3+ ion- based clinical agent. Herein, we report that gadonanotubes are also  ultrasensitive pH-smart probes with their r1/pH response  from pH 7.0-7.4 being an order of magnitude greater than  for any other MR contrast agent. This result suggests that  gadonanotubes might be excellent candidates for the  development of clinical agents for the early detection of  cancer where the extracellular pH of tumors can drop to  pH ) 7 or below. In the present study, gadonanotubes have  also been shown to maintain their integrity when challenged  ex vivo by phosphate-buffered saline solution, serum, heat,  and pH cycling. 
000117958 700__ $$aHartman, Keith B.
000117958 700__ $$0240388$$aLaus, Sabrina$$g148824
000117958 700__ $$aBolskar, Robert D.
000117958 700__ $$aMuthupillai, Raja
000117958 700__ $$0240250$$aHelm, Lothar$$g144957
000117958 700__ $$aToth, Eva
000117958 700__ $$0241569$$aMerbach, André E.$$g123257
000117958 700__ $$aWilson, Lon J.
000117958 773__ $$j8$$q415-419$$tNano Letters
000117958 909CO $$ooai:infoscience.tind.io:117958$$particle$$pSB
000117958 909C0 $$0252059$$pLCIB$$xU10103
000117958 937__ $$aLCIB-ARTICLE-2008-033
000117958 973__ $$aEPFL$$rREVIEWED$$sPUBLISHED
000117958 980__ $$aARTICLE