Infoscience

Review

Colinearity loops out

Modulation of chromatin structure has long been proposed to underlie the colinear regulation of Hox genes during animal development. In a recent paper, Chambeyron and Bickmore explore this possibility in retinoic acid-induced ES cells. They show that, while chromatin remodeling confers transcriptional competence to the gene cluster, subsequent sequential extrusion of genes from their chromosome territory may determine their coordinated expression in time

    Note:

    Department of Zoology and Animal Biology and National Program "Frontiers in Genetics", University of Geneva, CH-1211 Geneva, Switzerland

    Reference

    • UPDUB-REVIEW-2008-020

    Record created on 2008-02-27, modified on 2016-08-08

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