Colinearity loops out

Modulation of chromatin structure has long been proposed to underlie the colinear regulation of Hox genes during animal development. In a recent paper, Chambeyron and Bickmore explore this possibility in retinoic acid-induced ES cells. They show that, while chromatin remodeling confers transcriptional competence to the gene cluster, subsequent sequential extrusion of genes from their chromosome territory may determine their coordinated expression in time


Published in:
Dev Cell, 6, 6, 738-740
Year:
2004
Note:
Department of Zoology and Animal Biology and National Program "Frontiers in Genetics", University of Geneva, CH-1211 Geneva, Switzerland
Laboratories:




 Record created 2008-02-27, last modified 2018-01-28


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