000117875 001__ 117875
000117875 005__ 20180317094601.0
000117875 037__ $$aARTICLE
000117875 245__ $$aGenetic control of murine limb morphogenesis: relationships with human syndromes and evolutionary relevance
000117875 269__ $$a1998
000117875 260__ $$c1998
000117875 336__ $$aReviews
000117875 500__ $$aDepartment of Zoology and Animal Biology, University of Geneva, Sciences III, Switzerland
000117875 520__ $$aOver the past ten years, the discovery and functional characterisation of murine Hox genes has led to a better understanding of some of the molecular mechanisms underlying limb development. It has also shed some light on the potential genetic events which have accompanied the fin-to-limb transition, an evolutionary step of critical importance which opened the way to the evolution of higher vertebrates. This convergence between developmental biology and the sciences of evolution is one of the synergistic interface that has been established recently thanks to the use of genetic engineering and transgenic animals. The increasing number of human genetic syndromes which are derived from mutations in developmental control genes remind us that many human genetic diseases are nothing else but alterations in our developmental programme. Here, we illustrate these various issues by discussing the function of Hox genes during limb development
000117875 700__ $$aKondo, T.
000117875 700__ $$aHerault, Y.
000117875 700__ $$aZakany, J.
000117875 700__ $$g141236$$aDuboule, D.$$0240276
000117875 773__ $$j140$$tMol Cell Endocrinol$$k1-2$$q3-8
000117875 909CO $$preview$$ooai:infoscience.tind.io:117875$$pSV
000117875 909C0 $$0252099$$pUPDUB$$xU11705
000117875 937__ $$aUPDUB-REVIEW-2008-016
000117875 973__ $$rREVIEWED$$sPUBLISHED$$aOTHER
000117875 980__ $$aREVIEW