000117871 001__ 117871
000117871 005__ 20180317094601.0
000117871 037__ $$aARTICLE
000117871 245__ $$aDorso-ventral limb polarity and origin of the ridge: on the fringe of independence?
000117871 269__ $$a1997
000117871 260__ $$c1997
000117871 336__ $$aReviews
000117871 500__ $$aEuropean Molecular Biology Laboratory, Heidelberg, Germany
000117871 520__ $$aMolecular and developmental studies of limb pattern formation have recently gained widespread attention. The fact that vertebrate limbs are amenable to both genetic and embryological manipulations has established this model system as a valuable paradigm for studying vertebrate development. Limb buds are polarised along all three major axes and the establishment of the dorso-ventral (DV) polarity is dependent upon cues localised in the trunk, where a DV ectodermal interface is produced by confrontation of dorsal and ventral identities. By analogy to Drosophila imaginal disc development, this interface has been proposed to determine and position an ectodermal organising centre, the Apical Ectodermal Ridge (AER), controlling limb bud outgrowth. Recent fate mapping studies and studies of genes regulating DV limb polarity, AER formation and differentiation suggest, however, that DV patterning and AER induction, though coordinately regulated during limb bud outgrowth, may early on be more dissociated than expected
000117871 700__ $$aZeller, R.
000117871 700__ $$g141236$$aDuboule, D.$$0240276
000117871 773__ $$j19$$tBioessays$$k7$$q541-546
000117871 909CO $$preview$$ooai:infoscience.tind.io:117871$$pSV
000117871 909C0 $$0252099$$pUPDUB$$xU11705
000117871 937__ $$aUPDUB-REVIEW-2008-012
000117871 973__ $$rREVIEWED$$sPUBLISHED$$aOTHER
000117871 980__ $$aREVIEW