000117729 001__ 117729
000117729 005__ 20181203021112.0
000117729 0247_ $$2doi$$a10.1242/dev.01885
000117729 037__ $$aARTICLE
000117729 245__ $$aComparative analysis of genes downstream of the Hoxd cluster in developing digits and external genitalia
000117729 269__ $$a2005
000117729 260__ $$c2005
000117729 336__ $$aJournal Articles
000117729 500__ $$aNational Research Center (NCCR Zoology and Animal Biology, University of Geneva, Sciences III, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland.
000117729 520__ $$aMammalian Hox genes encode transcription factors that are crucial for proper morphogenesis along the various body axes. Despite their extensive structural and functional characterization, the nature of their target genes remains elusive. We have addressed this question by using DNA microarrays to screen for genes whose expression in developing distal forelimbs and genital eminences was significantly modified in the absence of the full Hoxd gene complement. This comparative approach not only identified specific candidate genes, but also allowed the examination of whether a similar Hox expression pattern in distinct tissues leads to the modulation of the same or different downstream genes. We report here a set of potential target genes, most of which were not previously known to play a role in the early stages of either limb or genital bud development. Interestingly, we find that the majority of these candidate genes are differentially expressed in both structures, although often at different times. This supports the idea that both appendices involve similar genetic controls, both upstream and downstream of the Hox gene family. These results highlight the surprising mechanistic relationship between these rather different body parts and suggest a common developmental strategy to build up the most distal appendicular structures of the body, i.e. the digits and the penis/clitoris.
000117729 700__ $$aCobb, J.
000117729 700__ $$0240276$$aDuboule, D.$$g141236
000117729 773__ $$j132$$k13$$q3055-67$$tDevelopment
000117729 909C0 $$0252099$$pUPDUB$$xU11705
000117729 909CO $$ooai:infoscience.tind.io:117729$$pSV$$particle
000117729 937__ $$aUPDUB-ARTICLE-2005-002
000117729 973__ $$aOTHER$$rREVIEWED$$sPUBLISHED
000117729 980__ $$aARTICLE