000117700 001__ 117700
000117700 005__ 20181203021112.0
000117700 0247_ $$2doi$$a10.1016/S0092-8674(00)80749-7
000117700 037__ $$aARTICLE
000117700 245__ $$aBreaking colinearity in the mouse HoxD complex
000117700 269__ $$a1999
000117700 260__ $$c1999
000117700 336__ $$aJournal Articles
000117700 500__ $$aDepartment of Zoology and Animal Biology, University of Geneva, Sciences III, Switzerland.
000117700 520__ $$aVertebrate Hox genes are activated in a spatiotemporal sequence that reflects their clustered organization. While this colinear relationship is a property of most metazoans with an anterior to posterior polarity, the underlying molecular mechanisms are unknown. Previous work suggested that Hox genes were made progressively available for transcription in the course of gastrulation, implying the existence of an element capable of initiating a repressive conformation, subsequently relieved from the clusters sequentially. We searched for this element by combining a genomic walk with successive transgene insertions upstream of the HoxD complex followed by a series of deletions. The largest deficiency induced posterior homeotic transformations coincidentally with an earlier activation of Hoxd genes. These data suggest that a regulatory element located upstream of the complex is necessary for setting up the early pattern of Hox gene colinear activation.
000117700 700__ $$aKondo, T.
000117700 700__ $$g141236$$aDuboule, D.$$0240276
000117700 773__ $$j97$$tCell$$k3$$q407-17
000117700 909C0 $$xU11705$$0252099$$pUPDUB
000117700 909CO $$pSV$$particle$$ooai:infoscience.tind.io:117700
000117700 937__ $$aUPDUB-ARTICLE-1999-003
000117700 973__ $$rREVIEWED$$sPUBLISHED$$aOTHER
000117700 980__ $$aARTICLE