000117689 001__ 117689
000117689 005__ 20181203021111.0
000117689 0247_ $$2doi$$a10.1002/(SICI)1097-0177(199704)208:4<454::AID-AJA2>3.0.CO;2-H
000117689 037__ $$aARTICLE
000117689 245__ $$aMale accessory sex organ morphogenesis is altered by loss of function of Hoxd-13
000117689 269__ $$a1997
000117689 260__ $$c1997
000117689 336__ $$aJournal Articles
000117689 500__ $$aUrology Department, Northwestern University Medical School, Chicago, Illinois, USA.
000117689 520__ $$aThe role of the Hox gene Hoxd-13 in postnatal morphogenesis of the male accessory sex organs was examined by correlating the distribution and temporal regulation of expression in the accessory sex organs of postnatal mice with morphologic abnormalities of Hoxd-13-deficient transgenic mice. Previous studies of Hoxd-13 expression in the perinatal period have shown a broad domain of expression in the lower genitourinary tract, with expression in both mesenchyme and epithelium; focal expression was also noted in the epithelium of the nascent ducts of the developing prostate. Quantitative RT-PCR studies of Hoxd-13 expression in the 5 day mouse confirm widespread expression in the accessory sex organs developing from both the Wolffian duct and the urogenital sinus. Expression is down-regulated with age, and a detailed time course of expression in the developing prostate shows that the level of Hoxd-13 expression correlates with morphogenetic activity in the development of the prostate ductal system. Transgenic Hoxd-13-deficient mice display multiple abnormalities in the male accessory sex organs. The most severe abnormalities were observed in organs exhibiting ductal branching during postnatal development and included diminished mesenchymal folding in the seminal vesicles, decreased size and diminished ductal branching in the ventral and dorsal prostate, and agenesis of the bulbourethral gland. We conclude that Hoxd-13 expression in the postnatal period correlates with a period of intense morphogenetic activity in accessory sex organ development and that the function of Hoxd-13 is evidenced by morphologic abnormalities in accessory sex organs of the Hoxd-13-deficient mutant.
000117689 700__ $$aPodlasek, C. A.
000117689 700__ $$0240276$$g141236$$aDuboule, D.
000117689 700__ $$aBushman, W.
000117689 773__ $$j208$$tDev Dyn$$k4$$q454-65
000117689 909C0 $$xU11705$$0252099$$pUPDUB
000117689 909CO $$pSV$$particle$$ooai:infoscience.tind.io:117689
000117689 937__ $$aUPDUB-ARTICLE-1997-006
000117689 973__ $$rREVIEWED$$sPUBLISHED$$aOTHER
000117689 980__ $$aARTICLE