000117683 001__ 117683
000117683 005__ 20181203021111.0
000117683 0247_ $$2doi$$a10.1006/dbio.1996.0137
000117683 037__ $$aARTICLE
000117683 245__ $$aFunctional equivalence and rescue among group 11 Hox gene products in vertebral patterning
000117683 269__ $$a1996
000117683 260__ $$c1996
000117683 336__ $$aJournal Articles
000117683 500__ $$aDepartment of Zoology and Animal Biology, University of Geneva, Switzerland.
000117683 520__ $$aHoxa-11 and Hoxd-11 are paralogous genes required for proper development of the vertebral column, the limbs, and the urogenital system. To further explore the functional relationship between these genes, as well as the potential rescue of one function by the other, we have introduced a Hoxd-11-expressing transgene into Hoxa-11/Hoxd-11 mutant genetic backgrounds. A range of phenotypes was observed, with transgenic mice displaying as few as four lumbar vertebrae while double mutant mice had as many as eight. When transgenic, double homozygote mutant animals showed six lumbar vertebrae, instead of the eight usually observed. The phenotypic rescue of these genotypes shows that the Hoxa-11 and Hoxd-11 products are functionally equivalent and that extra doses of Hoxd-11 can rescue Hoxa-11 loss of function.
000117683 700__ $$aZakany, J.
000117683 700__ $$aGerard, M.
000117683 700__ $$aFavier, B.
000117683 700__ $$aPotter, S. S.
000117683 700__ $$0240276$$aDuboule, D.$$g141236
000117683 773__ $$j176$$k2$$q325-8$$tDev Biol
000117683 909C0 $$0252099$$pUPDUB$$xU11705
000117683 909CO $$ooai:infoscience.tind.io:117683$$pSV$$particle
000117683 937__ $$aUPDUB-ARTICLE-1996-012
000117683 973__ $$aOTHER$$rREVIEWED$$sPUBLISHED
000117683 980__ $$aARTICLE