Expression of the homeobox Hox-4 genes and the specification of position in chick wing development
The chicken Hox-4 homeogenes, like those of the mouse, are coordinately expressed in partially overlapping domains during wing development. Local application of retinoic acid, a putative endogenous morphogen, induces de novo transcription of Hox-4 genes. The mirror-image patterns of Hox-4 gene expression, which are obtained in this way, correlate with the subsequent development of mirror-image patterns of digits. Hox-4 genes probably encode positional information.
European Molecular Biology Laboratory, Heidelberg, Germany.
Record created on 2008-02-25, modified on 2016-08-08