Resonant Doppler flow imaging and optical vivisection of retinal blood vessels
For Fourier domain optical coherence tomography any sample movement during camera integration causes blurring of interference fringes and as such reduction of sensitivity for flow detection. The proposed method overcomes this problem by phase-matching a reference signal to the sample motion. The interference fringes corresponding to flow signal will appear frozen across the detector whereas those of static sample structures will be blurred resulting in enhanced contrast for blood vessels. An electro-optic phase modulator in the reference arm, driven with specific phase cycles locked to the detection frequency, allows not only for qualitative but also for quantitative flow detection already from the relative signal intensities. First applications to extract in-vivo retinal flow and to visualize 3D vascularization, i.e. optical vivisection, are presented.
Keywords: (110.4500) Imaging systems ; Optical coherence tomography ; (110.6880) Imaging systems ; Three-dimensional image acquisition ; (170.3880) Medical optics and biotechnology ; Medical and biological imaging ; (170.4470) Medical optics and biotechnology ; Ophthalmology ; (170.4500) Medical optics and biotechnology ; Optical coherence tomography
Record created on 2008-02-25, modified on 2016-08-08