000116565 001__ 116565
000116565 005__ 20180317092339.0
000116565 037__ $$aARTICLE
000116565 245__ $$aAdherens junction proteins in tumour progression
000116565 269__ $$a1995
000116565 260__ $$c1995
000116565 336__ $$aReviews
000116565 500__ $$aAuthor address: Max-Delbruck Centre for Molecular Medicine, Berlin
000116565 520__ $$aThe loss of epithelial differentiation in carcinomas, which is accompanied by higher mobility and invasiveness of the tumour cells, is often a consequence of reduced intercellular adhesion. The primary cause of the "scattering" of cells in invasive carcinomas appears to be a disturbance of the integrity of intercellular junctions, often involving the cell adhesion molecule E-cadherin. Permanent and transient molecular mechanisms can lead to the impairment of junction integrity of epithelial cells and thus to the progression of carcinomas towards a more invasive state. These include downregulation of E-cadherin expression and interaction between the adherens junction protein beta-catenin and the tumour suppressor gene product APC
000116565 700__ $$aBirchmeier, W.
000116565 700__ $$0240230$$aHuelsken, J.$$g171552
000116565 700__ $$aBehrens, J.
000116565 773__ $$j24$$q129-140$$tCancer Surv
000116565 909CO $$ooai:infoscience.tind.io:116565$$preview$$pSV
000116565 909C0 $$0252084$$pUPHUELSKEN$$xU11259
000116565 937__ $$aCDTSO-REVIEW-1995-001
000116565 973__ $$aOTHER$$rREVIEWED$$sPUBLISHED
000116565 980__ $$aREVIEW