Adherens junction proteins in tumour progression

The loss of epithelial differentiation in carcinomas, which is accompanied by higher mobility and invasiveness of the tumour cells, is often a consequence of reduced intercellular adhesion. The primary cause of the "scattering" of cells in invasive carcinomas appears to be a disturbance of the integrity of intercellular junctions, often involving the cell adhesion molecule E-cadherin. Permanent and transient molecular mechanisms can lead to the impairment of junction integrity of epithelial cells and thus to the progression of carcinomas towards a more invasive state. These include downregulation of E-cadherin expression and interaction between the adherens junction protein beta-catenin and the tumour suppressor gene product APC


Published in:
Cancer Surv, 24, 129-140
Year:
1995
Note:
Author address: Max-Delbruck Centre for Molecular Medicine, Berlin
Laboratories:




 Record created 2008-02-13, last modified 2018-01-28


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