000115431 001__ 115431
000115431 005__ 20181203021040.0
000115431 0247_ $$2doi$$a10.1111/j.1600-0749.1992.tb00552.x
000115431 022__ $$a0893-5785
000115431 037__ $$aARTICLE
000115431 245__ $$aMolecular characterization of the mouse tyrosinase gene: pigment cell-specific expression in transgenic mice
000115431 260__ $$c1992
000115431 269__ $$a1992
000115431 336__ $$aJournal Articles
000115431 500__ $$aInstitute of Cell and Tumor Biology, German Cancer Research Center, Heidelberg.
000115431 520__ $$aTyrosinase is the key enzyme in melanin synthesis, and is expressed in the pigment epithelium of the retina, a cell layer derived from the optic cup; and in neural crest-derived melanocytes of skin, hair follicle, choroid, and iris. The tyrosinase gene has been cloned and shown to map to the well-characterized c-locus (albino locus) of the mouse. Subsequent studies demonstrated that a functional tyrosinase minigene was able to rescue the albino phenotype in transgenic mice. The transgene was expressed in a cell type-specific manner in skin and eye. During development of the mouse, the tyrosinase gene is expressed in the pigment epithelium of the retina as early as day 10.5 of gestation. In the hair follicle, tyrosinase gene expression is detected from day 16.5 onwards. This cell-type-specific expression is largely reproduced in transgenic mice. Our results suggest that sequences in the immediate vicinity of the mouse tyrosinase gene are sufficient to provide cell type-specificity and developmental regulation in melanocytes and the pigment epithelium.
000115431 700__ $$0240256$$aBeermann, F.$$g169239
000115431 700__ $$aSchmid, E.
000115431 700__ $$aGanss, R.
000115431 700__ $$aSchutz, G.
000115431 700__ $$aRuppert, S.
000115431 773__ $$j5$$k5 Pt 2$$q295-9$$tPigment Cell Res
000115431 909C0 $$0252092$$pGR-BEERMANN$$xU11779
000115431 909CO $$ooai:infoscience.tind.io:115431$$pSV$$particle
000115431 937__ $$aGR-BEERMANN-ARTICLE-1992-001
000115431 973__ $$aOTHER$$rREVIEWED$$sPUBLISHED
000115431 980__ $$aARTICLE