Store operated calcium entry

Many hormones, growth factors and neurotransmitters stimulate the production of inositol 1,4,5-trisphosphate evoking the release of calcium from intracellular stores. The depletion of these intracellular calcium stores subsequently activates a voltage-independent plasma membrane calcium influx in many cell types. This store-operated calcium influx is essential for generating prolonged cytosolic calcium signals and for refilling the intracellular calcium stores. Recent studies suggest that the store-operated calcium channels may be encoded by the trp family of genes, which show structural homology to voltage-operated channels. Ankyrin-like repeats encoded by trp may be involved in regulating the channel by a direct interaction with the inositol 1,4,5-trisphosphate receptor on the intracellular calcium stores.

Published in:
Seminars in the Neurosciences, 8, 5, 293-300
Univ cambridge,dept zool,babraham inst,lab mol signalling,cambridge cb2 3ej,england.

 Record created 2007-12-18, last modified 2018-03-17

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