Local and Global Cytosolic Ca-2+ Oscillations Evoked by Agonists and Inositol Trisphosphate

The agonists acetylcholine (ACh) and cholecystokinin (CCK) evoke oscillating cytosolic Ca2+ signals in pancreatic acinar cells. Low agonist concentrations evoke local cytosolic Ca2+ spikes confined to the secretory pole region and intracellular inositol trisphosphate application can mimick this action. These spikes can occur alone, repetitively or precede longer lasting Ca2+ transients that spread throughout the cell. ACh and CCK evoke different Ca2+ signal patterns also influenced by the resting cytosolic Ca2+ concentration ([Ca2+]i). Ca2+ pump-mediated Ca2+ extrusion occurs in a pulsatile manner and is synchronous with the transient elevations of [Ca2+]i.


    Univ cambridge,dept zool,afrc,molec signalling lab,cambridge cb2 3ej,england.


    • LSENS-REVIEW-2007-002

    Record created on 2007-12-18, modified on 2017-05-12


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