000115033 001__ 115033
000115033 005__ 20180317092841.0
000115033 037__ $$aARTICLE
000115033 245__ $$aReceptor-activated cytoplasmic Ca2+ oscillations in pancreatic acinar cells: generation and spreading of Ca2+ signals
000115033 269__ $$a1991
000115033 260__ $$c1991
000115033 336__ $$aReviews
000115033 500__ $$aMRC Secretory Control Research Group, University of Liverpool, UK.
000115033 520__ $$aReceptor-activated cytoplasmic Ca2+ oscillations have been investigated using both single cell microfluorometry and voltage-clamp recording of Ca(2+)-dependent Cl- current in single internally perfused acinar cells. In these cells there is direct experimental evidence showing that the ACh-evoked [Ca2+]i fluctuations are due to an inositol trisphosphate-induced small steady Ca2+ release which in turn evokes repetitive Ca2+ spikes via a caffeine-sensitive Ca(2+)-induced Ca2+ release process. There is indirect evidence suggesting that receptor-activation in addition to generating the Ca2+ releasing messenger, inositol trisphosphate, also produces another regulator involved in the control of Ca2+ signal spreading. Intracellular inositol trisphosphate or Ca2+ infusion produce short duration repetitive spikes confined to the cytoplasmic area close to the plasma membrane, but these signals can be made to progress throughout the cell by addition of caffeine or by receptor activation.
000115033 700__ $$aPetersen, O. H.
000115033 700__ $$aGallacher, D. V.
000115033 700__ $$aWakui, M.
000115033 700__ $$aYule, D. I.
000115033 700__ $$0243169$$g157467$$aPetersen, C. C.
000115033 700__ $$aToescu, E. C.
000115033 773__ $$j12$$tCell Calcium$$k2-3$$q135-144
000115033 909CO $$preview$$ooai:infoscience.tind.io:115033$$pSV
000115033 909C0 $$0252149$$pLSENS$$xU10837
000115033 937__ $$aLSENS-REVIEW-2007-001
000115033 973__ $$rREVIEWED$$sPUBLISHED$$aOTHER
000115033 980__ $$aREVIEW