000114992 001__ 114992
000114992 005__ 20181203021034.0
000114992 037__ $$aARTICLE
000114992 245__ $$aA generalized profile syntax for biomolecular sequence motifs and its function in automatic sequence interpretation
000114992 269__ $$a1994
000114992 260__ $$c1994
000114992 336__ $$aJournal Articles
000114992 500__ $$aSwiss Institute for Experimental Cancer Research, Epalinges s/Lausanne, Switzerland.
000114992 520__ $$aA general syntax for expressing biomolecular sequence motifs is described, which will be used in future releases of the PROSITE data bank and in a similar collection of nucleic acid sequence motifs currently under development. The central part of the syntax is a regular structure which can be viewed as a generalization of the profiles introduced by Gribskov and coworkers. Accessory features implement specific motif search strategies and provide information helpful for the interpretation of predicted matches. Two contrasting examples, representing E. coli promoters and SH3 domains respectively, are shown to demonstrate the versatility of the syntax, and its compatibility with diverse motif search methods. It is argued, that a comprehensive machine-readable motif collection based on the new syntax, in conjunction with a standard search program, can serve as a general-purpose sequence interpretation and function prediction tool.
000114992 700__ $$0244404$$g113607$$aBucher, P.
000114992 700__ $$aBairoch, A.
000114992 773__ $$j2$$tProc Int Conf Intell Syst Mol Biol$$q53-61
000114992 909C0 $$xU11780$$0252244$$pGR-BUCHER
000114992 909CO $$pSV$$particle$$ooai:infoscience.tind.io:114992
000114992 937__ $$aGR-BUCHER-ARTICLE-2007-001
000114992 973__ $$rREVIEWED$$sPUBLISHED$$aOTHER
000114992 980__ $$aARTICLE