000114917 001__ 114917
000114917 005__ 20190316234108.0
000114917 0247_ $$2doi$$a10.1093/nar/gkm343
000114917 037__ $$aARTICLE
000114917 245__ $$aMADAP, a flexible clustering tool for the interpretation of one-dimensional genome annotation data
000114917 269__ $$a2007
000114917 260__ $$c2007
000114917 336__ $$aJournal Articles
000114917 520__ $$aA recurring task in the analysis of mass genome annotation data from high-throughput technologies is the identification of peaks or clusters in a noisy signal profile. Examples of such applications are the definition of promoters on the basis of transcription start site profiles, the mapping of transcription factor binding sites based on ChIP-chip data and the identification of quantitative trait loci (QTL) from whole genome SNP profiles. Input to such an analysis is a set of genome coordinates associated with counts or intensities. The output consists of a discrete number of peaks with respective volumes, extensions and center positions. We have developed for this purpose a flexible one-dimensional clustering tool, called MADAP, which we make available as a web server and as standalone program. A set of parameters enables the user to customize the procedure to a specific problem. The web server, which returns results in textual and graphical form, is useful for small to medium-scale applications, as well as for evaluation and parameter tuning in view of large-scale applications, requiring a local installation. The program written in C++ can be freely downloaded from ftp://ftp.epd.unil.ch/pub/software/unix/madap. The MADAP web server can be accessed at http://www.isrec.isb-sib.ch/madap/.
000114917 700__ $$aSchmid, C. D.
000114917 700__ $$aSengstag, T.
000114917 700__ $$0244404$$g113607$$aBucher, P.
000114917 700__ $$aDelorenzi, M.
000114917 773__ $$j35$$tNucleic Acids Res$$kSuppl 2$$qW201-5
000114917 8564_ $$uhttps://infoscience.epfl.ch/record/114917/files/Nucl.%20Acids%20Res.-2007-Schmid-W201-5.pdf$$zPublisher's version$$s1221328$$yPublisher's version
000114917 909C0 $$xU11780$$0252244$$pGR-BUCHER
000114917 909CO $$ooai:infoscience.tind.io:114917$$qGLOBAL_SET$$pSV$$particle
000114917 917Z8 $$x182396
000114917 937__ $$aGR-BUCHER-ARTICLE-2007-006
000114917 973__ $$rREVIEWED$$sPUBLISHED$$aOTHER
000114917 980__ $$aARTICLE