000114887 001__ 114887
000114887 005__ 20181203021032.0
000114887 037__ $$aARTICLE
000114887 245__ $$aLong-range heterogeneity at the 3' ends of human mRNAs
000114887 269__ $$a2002
000114887 260__ $$c2002
000114887 336__ $$aJournal Articles
000114887 500__ $$aOffice of Information Technology, Ludwig Institute for Cancer Research, Switzerland.
000114887 520__ $$aThe publication of a draft of the human genome and of large collections of transcribed sequences has made it possible to study the complex relationship between the transcriptome and the genome. In the work presented here, we have focused on mapping mRNA 3' ends onto the genome by use of the raw data generated by the expressed sequence tag (EST) sequencing projects. We find that at least half of the human genes encode multiple transcripts whose polyadenylation is driven by multiple signals. The corresponding transcript 3' ends are spread over distances in the kilobase range. This finding has profound implications for our understanding of gene expression regulation and of the diversity of human transcripts, for the design of cDNA microarray probes, and for the interpretation of gene expression profiling experiments.
000114887 700__ $$aIseli, C.
000114887 700__ $$aStevenson, B. J.
000114887 700__ $$ade Souza, S. J.
000114887 700__ $$aSamaia, H. B.
000114887 700__ $$aCamargo, A. A.
000114887 700__ $$aBuetow, K. H.
000114887 700__ $$aStrausberg, R. L.
000114887 700__ $$aSimpson, A. J.
000114887 700__ $$0244404$$aBucher, P.$$g113607
000114887 700__ $$aJongeneel, C. V.
000114887 773__ $$j12$$k7$$q1068-74$$tGenome Res
000114887 909C0 $$0252244$$pGR-BUCHER$$xU11780
000114887 909CO $$ooai:infoscience.tind.io:114887$$pSV$$particle
000114887 937__ $$aGR-BUCHER-ARTICLE-2002-003
000114887 973__ $$aOTHER$$rREVIEWED$$sPUBLISHED
000114887 980__ $$aARTICLE