000114885 001__ 114885
000114885 005__ 20181203021032.0
000114885 0247_ $$2doi$$a10.1038/nature01251
000114885 037__ $$aARTICLE
000114885 245__ $$aNumerous potentially functional but non-genic conserved sequences on human chromosome 21
000114885 269__ $$a2002
000114885 260__ $$c2002
000114885 336__ $$aJournal Articles
000114885 500__ $$aDivision of Medical Genetics, 1 Rue Michel-Servet, University of Geneva Medical School and University Hospitals of Geneva, CH-1211 Geneva, Switzerland.
000114885 520__ $$aThe use of comparative genomics to infer genome function relies on the understanding of how different components of the genome change over evolutionary time. The aim of such comparative analysis is to identify conserved, functionally transcribed sequences such as protein-coding genes and non-coding RNA genes, and other functional sequences such as regulatory regions, as well as other genomic features. Here, we have compared the entire human chromosome 21 with syntenic regions of the mouse genome, and have identified a large number of conserved blocks of unknown function. Although previous studies have made similar observations, it is unknown whether these conserved sequences are genes or not. Here we present an extensive experimental and computational analysis of human chromosome 21 in an effort to assign function to sequences conserved between human chromosome 21 (ref. 8) and the syntenic mouse regions. Our data support the presence of a large number of potentially functional non-genic sequences, probably regulatory and structural. The integration of the properties of the conserved components of human chromosome 21 to the rapidly accumulating functional data for this chromosome will improve considerably our understanding of the role of sequence conservation in mammalian genomes.
000114885 700__ $$aDermitzakis, E. T.
000114885 700__ $$aReymond, A.
000114885 700__ $$aLyle, R.
000114885 700__ $$aScamuffa, N.
000114885 700__ $$aUcla, C.
000114885 700__ $$aDeutsch, S.
000114885 700__ $$aStevenson, B. J.
000114885 700__ $$aFlegel, V.
000114885 700__ $$0244404$$g113607$$aBucher, P.
000114885 700__ $$aJongeneel, C. V.
000114885 700__ $$aAntonarakis, S. E.
000114885 773__ $$j420$$tNature$$k6915$$q578-82
000114885 909C0 $$xU11780$$0252244$$pGR-BUCHER
000114885 909CO $$pSV$$particle$$ooai:infoscience.tind.io:114885
000114885 937__ $$aGR-BUCHER-ARTICLE-2002-001
000114885 973__ $$rREVIEWED$$sPUBLISHED$$aOTHER
000114885 980__ $$aARTICLE