000114839 001__ 114839
000114839 005__ 20181203021031.0
000114839 037__ $$aARTICLE
000114839 245__ $$aSignificant similarity and dissimilarity in homologous proteins
000114839 269__ $$a1992
000114839 260__ $$c1992
000114839 336__ $$aJournal Articles
000114839 500__ $$aDepartment of Mathematics, Stanford University, California 94305.
000114839 520__ $$aCommon practice emphasizes significant sequence similarities between different members of protein families. These similarities presumably reflect on evolutionary conservation of structurally and functionally essential residues. The nonconserved regions, on the other hand, may be either selectively neutral or differentiated. We propose several distributional sequence statistics (e.g., clustering of charged residues, compositional biases, and repetitive patterns) as indicators of differentiation events. These ideas are illustrated with various examples, including comparisons among G protein-coupled receptors, herpesvirus proteins, and GTPase-activating proteins.
000114839 700__ $$aKarlin, S.
000114839 700__ $$aBrendel, V.
000114839 700__ $$g113607$$aBucher, P.$$0244404
000114839 773__ $$j9$$tMol Biol Evol$$k1$$q152-67
000114839 909C0 $$xU11780$$0252244$$pGR-BUCHER
000114839 909CO $$pSV$$particle$$ooai:infoscience.tind.io:114839
000114839 937__ $$aGR-BUCHER-ARTICLE-1992-003
000114839 973__ $$rREVIEWED$$sPUBLISHED$$aOTHER
000114839 980__ $$aARTICLE