Strategy To Tether Organometallic Ruthenium-Arene Anticancer Compounds to Recombinant Human Serum Albumin
2007
Abstract
In order to utilize macromols. for drug targeting and delivery, a strategy to tether organometallic ruthenium-arene drugs to carrier protein mols. was developed. The approach involves the design of a drug fragment capable of conjugating to linker mols. on a modified carrier protein via hydrazone bond formation. The proof-of-concept using recombinant human serum albumin is described.
Details
Title
Strategy To Tether Organometallic Ruthenium-Arene Anticancer Compounds to Recombinant Human Serum Albumin
Author(s)
Ang, Wee Han ; Daldini, Elisa ; Juillerat-Jeanneret, Lucienne ; Dyson, Paul J.
Published in
Organometallics
Volume
46
Issue
22
Pages
9048-9050
Date
2007
Other identifier(s)
DAR: 11492
View record in Web of Science
View record in Web of Science
Laboratories
LCOM
Record Appears in
Scientific production and competences > SB - School of Basic Sciences > ISIC - Institute of Chemical Sciences and Engineering > LCOM - Laboratory of Organometallic and Medicinal Chemistry
Peer-reviewed publications
Work produced at EPFL
Journal Articles
Published
Peer-reviewed publications
Work produced at EPFL
Journal Articles
Published
Record creation date
2007-12-13