Strategy To Tether Organometallic Ruthenium-Arene Anticancer Compounds to Recombinant Human Serum Albumin
In order to utilize macromols. for drug targeting and delivery, a strategy to tether organometallic ruthenium-arene drugs to carrier protein mols. was developed. The approach involves the design of a drug fragment capable of conjugating to linker mols. on a modified carrier protein via hydrazone bond formation. The proof-of-concept using recombinant human serum albumin is described.
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Record created on 2007-12-13, modified on 2016-11-16