Role of Interferon-Gamma in Contact Hypersensitivity Assessed in Interferon-Gamma Receptor-Deficient Mice

The role of interferon-gamma (IFN gamma) in contact hypersensitivity induced by the haptens, oxazolone and 2,4,6-trinitro-chlorobenzene (TNCB), was investigated in mice with a targeted disruption of the IFN gamma receptor (IFN gamma-R-/-). The 24-h ear-swelling response to oxazolone or TNCB in sensitized animals was not significantly reduced by the disruption of IFN-gamma, signalling. Dermal mononuclear infiltrates (MN) and epidermal microabscesses, however, were clearly diminished in the mutant mice. The hapten-induced upregulation of intercellular-adhesion molecule-1 (ICAM-1) and major histocompatibility complex (MHC) class I in IFN gamma-R-/- mice was smaller when compared to wild-type mice. It is concluded that oxazolone- and TNCB-induced contact hypersensitivity is partially dependent on a functional IFN gamma system. While the cutaneous oedema is IFN gamma-independent, the mononuclear cell infiltration and epidermal microabscess formation are at least partly IFN gamma-dependent. Therefore, reduced cellular infiltrates are likely due to a reduced upregulation of ICAM-1 and class I antigen expression in IFN gamma-R-/- mice.

Published in:
Toxicology, 102, 3, 301-312
Univ Zurich,Inst Toxicol,Ch-8603 Schwerzenbach,Switzerland Swiss Fed Inst Toxicol,Ch-8603 Schwerzenbach,Switzerland Univ Zurich,Dept Biol Molec,Zurich,Switzerland

 Record created 2007-12-12, last modified 2020-07-30

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