The in vivo antiviral activity of interleukin-12 is mediated by gamma interferon

The injection of 20 ng of mouse interleukin-12 (IL-12) protects mice from a lethal infection with encephalomyocarditis virus. In vitro, an anti-gamma interferon (anti-IFN-gamma) monoclonal antibody but not an anti-IL-12 monoclonal antibody neutralizes the antiviral activity present in the supernatants of splenocytes stimulated with IL-12. Finally, IL-12 fails to protect 129 Sv/Ev IFN-gamma R0/0 mice against encephalomyocarditis virus infection. These results demonstrate that IL-12 exerts its antiviral activity through the induction of endogenous IFN-gamma.


Published in:
J Virol, 69, 12, 8147-50
Year:
1995
Note:
Pharma Research Gene Technology, F. Hoffmann La-Roche Ltd., Basel, Switzerland.
Laboratories:




 Record created 2007-12-12, last modified 2018-03-17


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