Journal article

The in vivo antiviral activity of interleukin-12 is mediated by gamma interferon

The injection of 20 ng of mouse interleukin-12 (IL-12) protects mice from a lethal infection with encephalomyocarditis virus. In vitro, an anti-gamma interferon (anti-IFN-gamma) monoclonal antibody but not an anti-IL-12 monoclonal antibody neutralizes the antiviral activity present in the supernatants of splenocytes stimulated with IL-12. Finally, IL-12 fails to protect 129 Sv/Ev IFN-gamma R0/0 mice against encephalomyocarditis virus infection. These results demonstrate that IL-12 exerts its antiviral activity through the induction of endogenous IFN-gamma.


    Pharma Research Gene Technology, F. Hoffmann La-Roche Ltd., Basel, Switzerland.


    • UPAGU-ARTICLE-1995-013

    Record created on 2007-12-12, modified on 2017-05-12


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