000114677 001__ 114677
000114677 005__ 20180317092010.0
000114677 037__ $$aARTICLE
000114677 245__ $$aImmune response in mice that lack the interferon-gamma receptor
000114677 269__ $$a1993
000114677 260__ $$c1993
000114677 336__ $$aJournal Articles
000114677 500__ $$aInstitute of Molecular Biology I, University of Zurich, Switzerland.
000114677 520__ $$aInterferon-gamma (IFN-gamma) exerts pleiotropic effects, including antiviral activity, stimulation of macrophages and natural killer cells, and increased expression of major histocompatibility complex antigens. Mice without the IFN-gamma receptor had no overt anomalies, and their immune system appeared to develop normally. However, mutant mice had a defective natural resistance, they had increased susceptibility to infection by Listeria monocytogenes and vaccinia virus despite normal cytotoxic and T helper cell responses. Immunoglobulin isotype analysis revealed that IFN-gamma is necessary for a normal antigen-specific immunoglobulin G2a response. These mutant mice offer the possibility for the further elucidation of IFN-gamma-mediated functions by transgenic cell- or tissue-specific reconstitution of a functional receptor.
000114677 700__ $$aHuang, S.
000114677 700__ $$aHendriks, W.
000114677 700__ $$aAlthage, A.
000114677 700__ $$aHemmi, S.
000114677 700__ $$aBluethmann, H.
000114677 700__ $$aKamijo, R.
000114677 700__ $$aVilcek, J.
000114677 700__ $$aZinkernagel, R. M.
000114677 700__ $$0240585$$aAguet, M.$$g168669
000114677 773__ $$j259$$k5102$$q1742-5$$tScience
000114677 909CO $$ooai:infoscience.tind.io:114677$$particle$$pSV
000114677 909C0 $$0252150$$pUPAGU$$xU11156
000114677 937__ $$aUPAGU-ARTICLE-1993-002
000114677 973__ $$aOTHER$$rREVIEWED$$sPUBLISHED
000114677 980__ $$aARTICLE