000114243 001__ 114243
000114243 005__ 20190316234059.0
000114243 0247_ $$2doi$$a10.1534/genetics.107.081166
000114243 02470 $$2DAR$$a12031
000114243 02470 $$2ISI$$a000252742200037
000114243 037__ $$aARTICLE
000114243 245__ $$aThe fixation of locally beneficial alleles in a metapopulation
000114243 269__ $$a2008
000114243 260__ $$c2008
000114243 336__ $$aJournal Articles
000114243 520__ $$aExtinction, recolonization and local adaption are common in natural spatially structured populations. Understanding their effect upon genetic variation is important for systems such as GMO management, or avoidance of drug resistance. Theoretical studies on the effect of extinction and recolonization upon genetic variance started appearing in the 1970’s, but the role of local adaption still has no good theoretical basis. Here we develop a model of a haploid species in a metapopulation in which a locally adapted beneficial allele is introduced. We study the effect of different spatial patterns of local adaption, and different metapopulation dynamics, upon the fixation probability of the beneficial allele. Controlling for the average selection pressure, we find that a small area of positive selection can significantly increase the global probability of fixation. However, local adaption becomes less important as extinction rate increases. Deme extinction and recolonization has a spatial smoothing effect which effectively reduces spatial variation in fitness.
000114243 6531_ $$alocal adaption
000114243 6531_ $$ametapopulation
000114243 6531_ $$aextinction
000114243 6531_ $$afixation
000114243 6531_ $$aprobability
000114243 700__ $$0240433$$aVuilleumier, S.$$g104163
000114243 700__ $$aYearsley, Jon M
000114243 700__ $$aPerrin, Nicolas
000114243 773__ $$j178$$k1$$q467-475$$tGenetics
000114243 8564_ $$s373156$$uhttps://infoscience.epfl.ch/record/114243/files/Pub_Genetics178.pdf$$yPublisher's version$$zPublisher's version
000114243 909C0 $$0252129$$pECOS$$xU11021
000114243 909CO $$ooai:infoscience.tind.io:114243$$particle$$pENAC$$qGLOBAL_SET
000114243 917Z8 $$x182396
000114243 937__ $$aECOS-ARTICLE-2007-059
000114243 973__ $$aEPFL$$rREVIEWED$$sPUBLISHED
000114243 980__ $$aARTICLE