000114243 001__ 114243
000114243 005__ 20181203021021.0
000114243 0247_ $$2doi$$a10.1534/genetics.107.081166
000114243 02470 $$2DAR$$a12031
000114243 02470 $$2ISI$$a000252742200037
000114243 037__ $$aARTICLE
000114243 245__ $$aThe fixation of locally beneficial alleles in a  metapopulation
000114243 269__ $$a2008
000114243 260__ $$c2008
000114243 336__ $$aJournal Articles
000114243 520__ $$aExtinction, recolonization and local adaption are common in  natural spatially structured populations. Understanding  their effect upon genetic variation is important for  systems such as GMO management, or avoidance of drug  resistance. Theoretical studies on the effect of extinction  and recolonization upon genetic variance started appearing  in the 1970’s, but the role of local adaption still has no  good theoretical basis. Here we develop a model of a  haploid species in a metapopulation in which a locally  adapted beneficial allele is introduced. We study the  effect of different spatial patterns of local adaption, and  different metapopulation dynamics, upon the fixation  probability of the beneficial allele. Controlling for the  average selection pressure, we find that a small area of  positive selection can significantly increase the global  probability of fixation.  However, local adaption becomes  less important as extinction rate increases. Deme  extinction and recolonization has a spatial smoothing  effect which effectively reduces spatial variation in  fitness.
000114243 6531_ $$alocal adaption
000114243 6531_ $$ametapopulation
000114243 6531_ $$aextinction
000114243 6531_ $$afixation
000114243 6531_ $$aprobability
000114243 700__ $$0240433$$aVuilleumier, S.$$g104163
000114243 700__ $$aYearsley, Jon M
000114243 700__ $$aPerrin, Nicolas
000114243 773__ $$j178$$k1$$q467-475$$tGenetics
000114243 8564_ $$s373156$$uhttps://infoscience.epfl.ch/record/114243/files/Pub_Genetics178.pdf$$yPublisher's version$$zPublisher's version
000114243 909C0 $$0252129$$pECOS$$xU11021
000114243 909CO $$ooai:infoscience.tind.io:114243$$particle$$pENAC$$qGLOBAL_SET
000114243 917Z8 $$x182396
000114243 937__ $$aECOS-ARTICLE-2007-059
000114243 973__ $$aEPFL$$rREVIEWED$$sPUBLISHED
000114243 980__ $$aARTICLE