Low- to high-throughput analysis of telomerase modulators with Telospot
We designed a method termed Telospot to discover and characterize telomerase modulators as anticancer drugs or chemical biology tools. Telospot is based on a highly efficient human telomerase expression system and the detection of telomerase DNA reaction products in macroarray format. Telospot offers a highly scalable, cost- and time-effective alternative to presently available telomerase assays, which are limited by the requirement for PCR, telomerase purification or technologies not amenable to high throughput.
 Swiss Institute for Experimental Cancer Research, Chemin des Boveresses 155, CH-1066 Epalinges, Switzerland.  Ecole Polytechnique Federale de Lausanne, School of Life Sciences, Station 15, CH-1015 Lausanne, Switzerland.  "Frontiers in Genetics" National Center for Competence in Research, quai Ernest-Ansermet 30, CH-1211 Geneva, Switzerland.  Present address: Institut National de la Sante et de la Recherche Medicale (INSERM), U758, Ecole Normale Superieure de Lyon, 46 allee d'Italie, F-69364 Lyon, France.  These authors contributed equally to this work.
Record created on 2007-11-20, modified on 2016-08-08