Self-organizing bio-inspired systems borrow three structural principles characteristic of living organisms: multicellular architecture, cellular division, and cellular differentiation. Implemented in silicon according to these principles, our cellular systems become able to grow, to selfreplicate, and to self-repair. The growth and branching processes, performed by the so-called Tom Thumb algorithm, lead thus to the configuration and cloning mechanisms of the cellular systems. The repair processes allow its cicatrization and regeneration mechanisms. The functional and hardware designs of these mechanisms constitute the core of this paper.