Disruption of amyloid-derived peptide assemblies through the controlled induction of a beta-sheet to alpha-helix transformation: application of the switch concept
2007
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Abstract
Reversal of amyloid formation through a controlled induced transformation from beta-sheet to sol. alpha-helix structures through the use of a switch element S could have an important consequences understanding the mechanisms of amyloid formation and clearance.
Details
Title
Disruption of amyloid-derived peptide assemblies through the controlled induction of a beta-sheet to alpha-helix transformation: application of the switch concept
Author(s)
Mimna, Richard ; Camus, Marie-Stephanie ; Schmid, Adrian ; Tuchscherer, Gabriele ; Lashuel, Hilal A. ; Mutter, Manfred
Published in
Angewandte Chemie, International Edition
Volume
46
Issue
15
Pages
2681-2684
Date
2007
Keywords
Conformational transition; Self-assembly; alpha-Helix; beta-Sheet (disruption of amyloid-derived peptide assemblies through the controlled induction of a beta-sheet to alpha-helix transformation); Amyloid Role: BSU (Biological study; unclassified); PRP (Properties); BIOL (Biological study) (disruption of amyloid-derived peptide assemblies through the controlled induction of a beta-sheet to alpha-helix transformation); Conformation; Secondary structure (protein; disruption of amyloid-derived peptide assemblies through the controlled induction of a beta-sheet to alpha-helix transformation); amyloid peptide beta sheet alpha helix secondary structure
Note
Reversal of amyloid formation through a controlled induced transformation from beta-sheet to sol. alpha-helix structures through the use of a switch element S could have an important consequences understanding the mechanisms of amyloid formation and clearance.
Other identifier(s)
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Record Appears in
Scientific production and competences > SV - School of Life Sciences > BMI - Brain Mind Institute > LMNN - Laboratory of Molecular Neurobiology and Neuroproteomics
Scientific production and competences > SB - School of Basic Sciences > SB Archives > LCBP - Laboratory of biomimetic and peptide chemistry
Peer-reviewed publications
Work produced at EPFL
Journal Articles
Published
Scientific production and competences > SB - School of Basic Sciences > SB Archives > LCBP - Laboratory of biomimetic and peptide chemistry
Peer-reviewed publications
Work produced at EPFL
Journal Articles
Published
Record creation date
2007-07-31